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Now that I have MalwareBytes, SuperAntiSpyware, Avast, and Microsoft Security Essentials, is this good for a multilayered approach or are there better programs to cover all the bases?

I haven’t seen anyone comment on this…Avast, and Microsoft Security Essentials are both full time security programs…they should not be installed and running at the same time

This site has helped a lot.
http://www.bleepingcomputer.com/virus-removal/
pay attention to any instructions that require manual participation on your part…they’re included for a reason
My 2 cents… clean the system restore files… and then after you are sure your OS is clean… create new and wipe out the old