This is a very minor issue, but an irritant nonetheless. I post it only on the chance that someone else might have a simple fix for this.
All my W10 computers were upgraded from W7, and this problem never happened in W7.
We leave the Num Lock permanently enabled for all the desktop computers. With only two computers out of four (a Dell with wireless M$ keyboard and an HP with USB keyboard), we have found W10 regularly turning Num Lock off; it turns back on easily, but it is a real irritant to start typing and find nothing happening! And with W10 we have started using PIN signon, so we notice quickly when the Num Lock has been disabled.
Have not yet found a correlation with some action that might be triggering this – I am pretty sure it is not sleep mode. Just seems to happen randomly.