macOS beta code suggests Apple will block users from sideloading unsupported iOS apps on M1 Macs
Based on internal code that is shared between recent iOS 14.4 beta versions and macOS Big Sur 11.2, Apple is implementing a new system that will block some iOS apps from running on the Mac. This, of course, will not affect the apps available on the Mac App Store.
Instead, this should prevent users from installing iOS apps that the developer has chosen not to offer on the Mac App Store for M1 Macs. In current versions of macOS, you can manually install iOS apps like Netflix, Instagram, and Facebook on an M1 Mac by using their respective IPA files downloaded under a valid Apple ID.